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KMID : 0361120130270030128
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Korean Journal of Transplantation
2013 Volume.27 No. 3 p.128 ~ p.131
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Successful Graft Recovery from Thrombotic Acute Kidney Injury in a Kidney Transplant Patient with Antiphospholipid Syndrome
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Choi Youn-Jeong
Lee Hye-Won
Yun Yu-Jung
Lee Young-Ki
Hwang Eu-Dong
Jeong Hyeon-Joo
Kim Beom-Seok
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Abstract
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Antiphospholipid syndrome nephropathy (APSN) is well documented in the literature as the renal involvement of the antiphospholipid syndrome (APS). A review of literature also shows that among antiphospholipid antibodies, lupus anticoagulant (LA) positivity is recognized as the strongest risk factor for APSN. In addition, APSN is also known to be associated with a poor functional outcome in the first posttransplant year. Therefore, it is a general belief that renal transplantation may be life threatening in APS patients. Furthermore, the presence of LA at the time of transplantation is particularly associated with a high rate of allograft APSN and the consequent poor transplantation outcomes. Here, we report the case that thrombotic acute kidney injury due to APSN after kidney transplantation can be successfully treated if anticoagulation therapy is timely applied with a prompt diagnosis.
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KEYWORD
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Antiphospholipid syndrome nephropathy, Antiphospholipid syndrome, Antiphospholipid antibodies, Lupus coagulation inhibitor, Kidney transplantation
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